After years of research and anticipation, insulin pills that could make it easier for millions of patients worldwide to manage diabetes are finally moving ahead in clinical trials and a step-closer to the medicine cabinet. That's among the topics highlighted in a two-part cover story on drug manufacturing in the current issue of Chemical & Engineering News (C&EN), ACS' weekly newsmagazine.
经过多年的研究和期待，可以使全世界数百万的患者更好的控制病情的胰岛素片剂终于在临床试验中向前发展，进一步接近成功。这是本期ACS新闻周刊化 学和工程杂志新闻制药版两部分封面故事强调的主题。
C&EN Senior Correspondent Ann Thayer notes that drug manufacturers have tried for years to develop oral insulin without much success. Insulin is a peptide hormone that people with diabetes currently take by injection to bring their blood sugar to within normal levels. But doing so requires uncomfortable, inconvenient injections that can make patients reluctant to use the drug frequently enough to adequately control their blood sugar. An oral form of insulin could help solve this problem. However, stomach acids and enzymes easily destroy insulin and other protein-based drugs. Scientists have had difficulty finding an effective way to eliminate this problem.
C&EN资深通讯记者Ann Thayer说，药物开发商试图研制口服胰岛素，但是多年来都没有成功。糖尿病患者通过注射胰岛素这种多肽类来把他们的血糖控制在正常水平。但是注射 很不舒服而且不方便的事情，患者不愿意经常使用足量的药物来恰当的控制他们的血糖。口服胰岛素有助于解决这个问题。但是，胃酸和消化酶很容易破坏胰 岛素和其他的类药物。科学家们很难找到一种有效的办法来解决这个问题。
They've responded to this challenge by developing special coatings for insulin pills that prevent stomach acid from destroying them. Scientists also are using additives that make it easier for the intestine to absorb large molecules like insulin. After years of setbacks, signs of success may be at hand. Several insulin pills are now in various stages of clinical trials, and proof of concept may allow them to move into late-stage and more rigorous clinical testing. Only time will tell, however, whether these much-anticipated pills will make it to the market.
科学家们研究出特制的糖衣包被胰岛素片来防止胃酸的破坏，从而回应这一挑战。科学家们还在片剂中应用添加剂，它们能够促进胃肠道对大分子物质像胰岛素的吸 收。经过许多年的失败，有迹象表明，科学家们正在走向成功。几种胰岛素片剂正处于临床试验的不同阶段，而且还可能进入后一阶段甚至更严格的临床测试。但 是，这些期待已久的片剂能否进入市场，还需要时间来证实。
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比针剂更好的胰岛素药丸正处于临床试验中
2010-06-09 18:12:38 来源：丁香园 作者： 评论： 点击：
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